Type 2 helper T cells convert into Interleukin-13-expressing follicular helper T cells after antigen repriming

Anaphylaxis caused by allergen sensitization and vaccination is a serious health concern. The severity of anaphylaxis associated with the presence immunoglobulin E (IgE) antibodies that bind to allergens high affinity. Here, we report development unique Interleukin-13 (IL-13)-producing follicular helper T (TFH) cell subset, designated TFH2 cells, which tightly production high-affinity IgE antibodies. cells had transcriptionally hybrid phenotype between TH2 TFH express GATA-binding protein 3 (Gata3) B-cell/CLL lymphoma 6 (BCL-6), respectively. Adaptive transfer experiments demonstrated type 2 (TH2) were capable differentiating into upon secondary antigen stimulation. (TFH2) conversion process was entirely attenuated in cell-specific deficient mice Bcl6 (Bcl6f/f cd4-cre; Bcl6ΔT). Moreover, IL-13 defective partially inhibited responses significantly decreased IgE, even though intact. Therefore, from controlled selective enrichment IgE+ B-cells affinity for allergens. A previously undefined TFH2, likely contributes responses. This suggests accumulation antigen-specific human patients allergies high-risk factor IgE-dependent allergic diseases.